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ターゲット

Estrogen Receptor/ERR Estrogen Receptor/ERR

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天然化合物

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T15249	Estrogen receptor modulator 1		Estrogen Receptor/ERR
	Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...		Estrogen Receptor/ERR
T78646	Estrogen receptor antagonist 8		Estrogen/progestogen Receptor
	Estrogen receptor antagonist 8 acts as an estrogen receptor (ER) antagonist with anti-uterine activity and potential anti-tumorigenic activity and can be used to study ovarian dysfunction.		Estrogen/progestogen Receptor
T40893	Estrogen receptor modulator 6
	Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for...
T11236	Giredestrant tartrate	Estrogen receptor antagonist 1	Estrogen Receptor/ERR , Others
	Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure o...		Estrogen Receptor/ERR , Others
T11237	Camizestrant	Estrogen receptor antagonist 2	Estrogen Receptor/ERR
	Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1].		Estrogen Receptor/ERR
T4388	PHTPP		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	PHTPP is a selective ERβ antagonist.
T7904	SR 19881		Estrogen/progestogen Receptor
	SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).		Estrogen/progestogen Receptor
T8984	FLTX1		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,...
T63277	Estrogen receptor antagonist 2
	Estrogen receptor antagonist 2 is a selective down-regulator of estrogen receptor. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. estrogen receptor antagonist 2 has re...
T63914	Estrogen receptor antagonist 3
	Estrogen receptor antagonist 3 is a potent degradation agent of the estrogen receptor (ER). Estrogen signalling systems play an important role in the regulation of cell growth, differentiation and apoptosis, and Estrogen...
T63106	Estrogen receptor antagonist 4
	Estrogen Receptor Antagonist 4 is a potent inhibitor of the estrogen receptor (ER), crucial for regulating cell growth, differentiation, and apoptosis. This compound holds promise for cancer research[1].
T79109	Estrogen receptor modulator 8		Estrogen Receptor/ERR
	Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) and effectively hampers MCF-7 cell proliferation (IC50 = 0....		Estrogen Receptor/ERR
T62952	Estrogen receptor antagonist 5
	Estrogen receptor antagonist 5 is a potent antagonist of the Estrogen receptor. Estrogen receptor (Estrogen receptor) is a ligand-activated transcriptional regulatory protein that interacts with endogenous estrogens and ...
T63582	Estrogen receptor antagonist 1
	Estrogen receptor antagonist 1 is a potent antagonist of the estrogen receptor. Estrogen receptor antagonist 1 has shown research potential in breast cancer disease.
T79064	Estrogen receptor modulator 7		Estrogen Receptor/ERR
	Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].		Estrogen Receptor/ERR
T60293	Estrogen receptor-IN-1
	Estrogen receptor-IN-1 (compound 16) is an effective estrogen receptor (ER) inhibitor with IC 50 s of 13, 5μM for ERα and Erβ, respectively [1].
T39710	ARV-471	Vepdegestrant	Estrogen Receptor/ERR , PROTACs
	ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.		Estrogen Receptor/ERR , PROTACs
T62953	Estrogen receptor antagonist 6
	Estrogen receptor antagonist 6 is a potent antagonist of the Estrogen receptor. Estrogen receptor is a ligand-activated transcriptional regulatory protein that interacts with endogenous estrogens and mediates the inducti...
T61909	Estrogen receptor antagonist 7
	Estrogen Receptor Antagonist 7 (Compound 13) is a potent antagonist of estrogen receptors (ER), demonstrating antiproliferative effects against breast and ovarian cancer cells, along with anticancer and anti-uterotrophic...
T82439	Estrogen receptor modulator 10		Estrogen Receptor/ERR
	Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, ...		Estrogen Receptor/ERR
T16566	Propyl pyrazole triol	PPT	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ...
T20625	Prochloraz	Sporgon,Prelude	Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
	Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T7644	DPN	Diarylpropionitrile	Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
	DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
T62311	Estrogen receptor β antagonist 2
	Estrogen receptor β antagonist 2 is a selective, potent estrogen receptor β (ERβ) antagonist that acts on Erα (IC50: 109.10 μM) and Erβ (IC50: 0.63 μM).
T7389	G15		Estrogen Receptor/ERR
	G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)		Estrogen Receptor/ERR
T15364	G-1		Estrogen Receptor/ERR , GPR
	G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).		Estrogen Receptor/ERR , GPR
T62764	Estrogen receptor α antagonist 1
	Estrogen receptor α antagonist 1 (compound 35) is a highly selective estrogen receptor α antagonist that acts on estrogen receptor α (IC50: 0.02 μM), estrogen receptor β (IC50. Estrogen receptor α antagonist 1 (compound ...
T0593	XCT790		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
	XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T14987	CMP8		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, res...
T3975	AZD9496		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T5531	GSK-4716		Estrogen Receptor/ERR
	GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand		Estrogen Receptor/ERR
T3958	WAY-200070	WAY 200070	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T1216	Diethylstilbestrol	Stilbestrol,DES	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders.
T8370	GSK5182		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Reactive Oxygen Species
	GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T13443	(R)-Equol	(+)-Equol	Estrogen/progestogen Receptor
	(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.		Estrogen/progestogen Receptor
T6306	Erteberel	LY500307	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T5633	H3B-5942		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T6533	Hexestrol	Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T2567	Etonogestrel	3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
	Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T13674	Elacestrant	RAD1901	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .
T0035	Dienestrol	Restrol,Dehydrostilbestrol,Dienoestrol,Cycladiene	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.
T13507	4,4'-Iminodiphenol	Leucoindophenol	Estrogen/progestogen Receptor
	4,4'-Iminodiphenol (Leucoindophenol) is an inactive estrogen receptor ligand with a diphenylamine backbone.		Estrogen/progestogen Receptor
T0168	Estradiol (cypionate)	Depofemin,Estradiol cypionate	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T7223	Gestrinone	R 2323	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Gestrinone (R 2323) is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM.
T0384	Estradiol benzoate	Benzoestrofol,Benzhormovarine,Benovocylin	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
T7313	Enclomiphene citrate	Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate	Estrogen Receptor/ERR
	Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic property		Estrogen Receptor/ERR
T4420	4-Hydroxytamoxifen	ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese...
T8981	WAY-169916	WAY 169916,WAY169916	NF-κB
	WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.		NF-κB
T11399	Giredestrant	GDC-9545	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand,...
T2544	Bazedoxifene acetate	WAY-TES 424,TSE 424,WAY-140424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).

Compounds

Estrogen receptor modulator 1

T15249

Synonym:

Target: Estrogen Receptor/ERR

Estrogen receptor antagonist 8

T78646

Synonym:

Target: Estrogen/progestogen Receptor

Estrogen receptor modulator 6

T40893

Synonym:

Target:

Giredestrant tartrate

T11236

Synonym: Estrogen receptor antagonist 1

Target: Estrogen Receptor/ERR, Others

Camizestrant

T11237

Synonym: Estrogen receptor antagonist 2

Target: Estrogen Receptor/ERR

PHTPP

T4388

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

SR 19881

T7904

Synonym:

Target: Estrogen/progestogen Receptor

FLTX1

T8984

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Estrogen receptor antagonist 2

T63277

Synonym:

Target:

Estrogen receptor antagonist 3

T63914

Synonym:

Target:

Estrogen receptor antagonist 4

T63106

Synonym:

Target:

Estrogen receptor modulator 8

T79109

Synonym:

Target: Estrogen Receptor/ERR

Estrogen receptor antagonist 5

T62952

Synonym:

Target:

Estrogen receptor antagonist 1

T63582

Synonym:

Target:

Estrogen receptor modulator 7

T79064

Synonym:

Target: Estrogen Receptor/ERR

Estrogen receptor-IN-1

Synonym: Vepdegestrant

Target: Estrogen Receptor/ERR, PROTACs

Estrogen receptor antagonist 6

T62953

Synonym:

Target:

Estrogen receptor antagonist 7

T61909

Synonym:

Target:

Estrogen receptor modulator 10

T82439

Synonym:

Target: Estrogen Receptor/ERR

Propyl pyrazole triol

T16566

Synonym: PPT

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Prochloraz

T20625

Synonym: Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

DPN

T7644

Synonym: Diarylpropionitrile

Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy

Estrogen receptor β antagonist 2

Target: Estrogen Receptor/ERR

G-1

T15364

Synonym:

Target: Estrogen Receptor/ERR, GPR

Estrogen receptor α antagonist 1

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy

CMP8

T14987

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

AZD9496

T3975

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

GSK-4716

T5531

Synonym:

Target: Estrogen Receptor/ERR

WAY-200070

T3958

Synonym: WAY 200070

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Diethylstilbestrol

T1216

Synonym: Stilbestrol,DES

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

GSK5182

T8370

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Reactive Oxygen Species

(R)-Equol

T13443

Synonym: (+)-Equol

Target: Estrogen/progestogen Receptor

Erteberel

T6306

Synonym: LY500307

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

H3B-5942

T5633

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Hexestrol

T6533

Synonym: Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Etonogestrel

T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Elacestrant

T13674

Synonym: RAD1901

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Dienestrol

T0035

Synonym: Restrol,Dehydrostilbestrol,Dienoestrol,Cycladiene

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

4,4'-Iminodiphenol

T13507

Synonym: Leucoindophenol

Target: Estrogen/progestogen Receptor

Estradiol (cypionate)

T0168

Synonym: Depofemin,Estradiol cypionate

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Gestrinone

T7223

Synonym: R 2323

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Estradiol benzoate

T0384

Synonym: Benzoestrofol,Benzhormovarine,Benovocylin

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Enclomiphene citrate

T7313

Synonym: Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate

Target: Estrogen Receptor/ERR

4-Hydroxytamoxifen

T4420

Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

WAY-169916

T8981

Synonym: WAY 169916,WAY169916

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Bazedoxifene acetate

T2544

Synonym: WAY-TES 424,TSE 424,WAY-140424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

カタログ番号	製品名	別名	ターゲット
TN1052	Lindleyin		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
T13768	(+)-Medicarpin		Estrogen/progestogen Receptor
	(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo...		Estrogen/progestogen Receptor
T5S0543	Isocurcumenol		Apoptosis , Estrogen Receptor/ERR , Reductase
	1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).		Apoptosis , Estrogen Receptor/ERR , Reductase
T3665	Tectoridin	Shekanin	Estrogen Receptor/ERR , Reductase
	Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an...		Estrogen Receptor/ERR , Reductase
T3855	Tracheloside		Estrogen Receptor/ERR , Phosphorylase
	Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).		Estrogen Receptor/ERR , Phosphorylase
T0301	Ethisterone	17α-Ethynyltestosterone,Pregneninolone	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone.
TQ0295	Coumestrol		Estrogen Receptor/ERR
	Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.		Estrogen Receptor/ERR
T13542	α-Zearalenol		Estrogen Receptor/ERR
	α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).		Estrogen Receptor/ERR
T3325	Liquiritigenin	4',7-Dihydroxyflavanone	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3913	Saikosaponin D		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
T4000	(±)-Equol	Equol,(R,S)-Equol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite
	(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu...
T3846	Bavachin	Corylifolin	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bavachin (Corylifolin) is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
T1009	Estrone	Oestrone,Fluoroethyl,Aquacrine	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr...
TMA1644	Segetalin B		Estrogen Receptor/ERR
	Segetalin B is a natural product from Vaccaria segetalis (Neck.) Garcke, has estrogen-like activity.		Estrogen Receptor/ERR
T1571	Estriol	NSC-12169,Oestriol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , MRP , Endogenous Metabolite
	Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is...
T3840	Dihydroresveratrol	3,4',5-Trihydroxybibenzyl	Estrogen Receptor/ERR , Others
	Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are ...		Estrogen Receptor/ERR , Others
T2810	(20S)-Protopanaxatriol	20(S)-APPT,g-PPT	Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor
	(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T3385	Gypenoside XVII	GP-17,Gynosaponin S	Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...		Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
T2177	Kaempferol	Kempferol,Robigenin	Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
TQ0274	27-Hydroxycholesterol	25(R)-27-hydroxy Cholesterol	Estrogen/progestogen Receptor , Liver X Receptor
			Estrogen/progestogen Receptor , Liver X Receptor
T0760	Cholesterol	Cholesterin,Cholesteryl alcohol	Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...
T2837	Chrysin	5, 7-Dihydroxyflavone,NSC 407436,5,7-Dihydroxyflavone	Estrogen Receptor/ERR , Antioxidant
	Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.		Estrogen Receptor/ERR , Antioxidant
T1048	Estradiol	E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be...
T6491	(-)-(S)-Equol	(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a...
T1424	Ethynyl estradiol	17α-Ethynylestradiol,Ethinyl Estradiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES...
T36857	Estrone sulfate sodium	Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate	Endogenous Metabolite
	Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigate...		Endogenous Metabolite
T0345	Estropipate	Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Estropipate (Piperazine estrone sulfate) is a natural estrogenic substance composed of estrone sulfate and piperazine.
T3806	Kaempferide	Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Influenza Virus , Antibacterial , Autophagy
	kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activatio...
T1549	Raloxifene hydrochloride	LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl	Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy
	Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol...
T2882	Genistin	Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside	Apoptosis , Estrogen Receptor/ERR , Others
	Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities		Apoptosis , Estrogen Receptor/ERR , Others
T7299	β-Estradiol 17-acetate	beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate	Estrogen Receptor/ERR , Others
	β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a metabolite of estradiol.		Estrogen Receptor/ERR , Others
T15248	Estetrol	Donesta	Estrogen Receptor/ERR , Endogenous Metabolite
	Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver during pregnancy.Estetrol has effects on the endometrium or cent...		Estrogen Receptor/ERR , Endogenous Metabolite
TN1918	Medicarpin		Apoptosis , BCL , ROS , JNK
	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in add...		Apoptosis , BCL , ROS , JNK
T3717	Hinokitiol	4-Isopropyltropolone,β-thujaplicin	DNA Methyltransferase , Virus Protease , Estrogen/progestogen Receptor , Nrf2
	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent...
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
TN1567	Delphinidin chloride		Estrogen Receptor/ERR , VEGFR
	Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...		Estrogen Receptor/ERR , VEGFR
T36914	2-Hydroxyanthraquinone		Others
	2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)...		Others
T39003	4',2-Dihydroxy-4,6-dimethoxydihydrochalcone
	4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, exhibits a significant binding affinity for the estrogen receptor in bovine uterine tissue, with an IC50 value of 15 μM.
TN4383	Kazinol U		IL Receptor , IκB/IKK , NOS , NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-...		IL Receptor , IκB/IKK , NOS , NF-κB
TN6366	Lupinalbin A
	Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine...
TN3539	Broussonin A		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-lucife...		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt
TN5456	Isoerysenegalensein E
	Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 ...
TN5164	Trans-Hinokiresinol		IL Receptor , TNF , NOS , LTR
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyaso...		IL Receptor , TNF , NOS , LTR
TMA0424	Martynoside		ROS
	Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the me...		ROS
TN3802	Dehydrodiconiferyl alcohol		Estrogen/progestogen Receptor
	Dehydrodiconiferyl alcohol (DHCA) is a lignan isolated from calabash that inhibits osteoclast differentiation and oophorectomy induced bone loss by acting as an estrogen receptor agonist.		Estrogen/progestogen Receptor
T35667	Napyradiomycin A1	Napyradiomycin A1
	Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Nap...
TN3084	5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone		Estrogen Receptor/ERR , Others
	5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 uM. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-dipren...		Estrogen Receptor/ERR , Others

天然物製品

Lindleyin

TN1052

Synonym:

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

(+)-Medicarpin

T13768

Synonym:

Target: Estrogen/progestogen Receptor

Isocurcumenol

T5S0543

Synonym:

Target: Apoptosis, Estrogen Receptor/ERR, Reductase

Tectoridin

T3665

Synonym: Shekanin

Target: Estrogen Receptor/ERR, Reductase

Tracheloside

T3855

Synonym:

Target: Estrogen Receptor/ERR, Phosphorylase

Ethisterone

T0301

Synonym: 17α-Ethynyltestosterone,Pregneninolone

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Coumestrol

TQ0295

Synonym:

Target: Estrogen Receptor/ERR

α-Zearalenol

T13542

Synonym:

Target: Estrogen Receptor/ERR

Liquiritigenin

T3325

Synonym: 4',7-Dihydroxyflavanone

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Saikosaponin D

T3913

Synonym:

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

(±)-Equol

T4000

Synonym: Equol,(R,S)-Equol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite

Bavachin

T3846

Synonym: Corylifolin

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Estrone

T1009

Synonym: Oestrone,Fluoroethyl,Aquacrine

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Segetalin B

TMA1644

Synonym:

Target: Estrogen Receptor/ERR

Estriol

T1571

Synonym: NSC-12169,Oestriol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, MRP, Endogenous Metabolite

Dihydroresveratrol

T3840

Synonym: 3,4',5-Trihydroxybibenzyl

Target: Estrogen Receptor/ERR, Others

(20S)-Protopanaxatriol

T2810

Synonym: 20(S)-APPT,g-PPT

Target: Apoptosis, Estrogen Receptor/ERR, Glucocorticoid Receptor, Estrogen/progestogen Receptor, Liver X Receptor

Gypenoside XVII

T3385

Synonym: GP-17,Gynosaponin S

Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite

Kaempferol

T2177

Synonym: Kempferol,Robigenin

Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy

27-Hydroxycholesterol

TQ0274

Synonym: 25(R)-27-hydroxy Cholesterol

Target: Estrogen/progestogen Receptor, Liver X Receptor

Cholesterol

T0760

Synonym: Cholesterin,Cholesteryl alcohol

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Chrysin

T2837

Synonym: 5, 7-Dihydroxyflavone,NSC 407436,5,7-Dihydroxyflavone

Target: Estrogen Receptor/ERR, Antioxidant

Estradiol

T1048

Synonym: E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

(-)-(S)-Equol

T6491

Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Ethynyl estradiol

T1424

Synonym: 17α-Ethynylestradiol,Ethinyl Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Estrone sulfate sodium

T36857

Synonym: Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate

Target: Endogenous Metabolite

Estropipate

T0345

Synonym: Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

kaempferide

T3806

Synonym: Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Influenza Virus, Antibacterial, Autophagy

Raloxifene hydrochloride

T1549

Synonym: LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy

Genistin

T2882

Synonym: Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside

Target: Apoptosis, Estrogen Receptor/ERR, Others

β-Estradiol 17-acetate

T7299

Synonym: beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate

Target: Estrogen Receptor/ERR, Others

Estetrol

T15248

Synonym: Donesta

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Medicarpin

TN1918

Synonym:

Target: Apoptosis, BCL, ROS, JNK

Hinokitiol

T3717

Synonym: 4-Isopropyltropolone,β-thujaplicin

Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Delphinidin chloride

TN1567

Synonym:

Target: Estrogen Receptor/ERR, VEGFR

2-Hydroxyanthraquinone

T36914

Synonym:

Target: Others

4',2-Dihydroxy-4,6-dimethoxydihydrochalcone

Target: IL Receptor, IκB/IKK, NOS, NF-κB

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Isoerysenegalensein E

Target: IL Receptor, TNF, NOS, LTR

Dehydrodiconiferyl alcohol

TN3802

Synonym:

Target: Estrogen/progestogen Receptor

Napyradiomycin A1

T35667

Synonym: Napyradiomycin A1

Target:

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

TN3084

Synonym:

Target: Estrogen Receptor/ERR, Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00762	ER alpha Protein, Human, Recombinant (His)	Human	E. coli
	Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPY-03496	EBAG9 Protein, Human, Recombinant (His)	Human	E. coli
	RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen ...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPH-01305	ER beta Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ...
TMPY-01660	SULT1E1 Protein, Human, Recombinant (His)	Human	E. coli
	Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catal...
TMPH-01304	ER beta Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ...
TMPJ-00705	BCAS2 Protein, Human, Recombinant (His, T7)	Human	E. coli
	Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell li...
TMPJ-00056	AG-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcin...
TMPJ-00253	OPG Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulat...
TMPY-04422	Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotran...
TMPY-02214	OTUB1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla...

ER alpha Protein, Human, Recombinant (His)

TMPJ-00762

Species: Human

Expression System: E. coli

EBAG9 Protein, Human, Recombinant (His)

TMPY-03496

Species: Human

Expression System: E. coli

C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

ER beta Protein, Human, Recombinant (His)

TMPH-01305

Species: Human

Expression System: P. pastoris (Yeast)

SULT1E1 Protein, Human, Recombinant (His)

TMPY-01660

Species: Human

Expression System: E. coli

ER beta Protein, Human, Recombinant (E. coli, His)

TMPH-01304

Species: Human

Expression System: E. coli

BCAS2 Protein, Human, Recombinant (His, T7)

TMPJ-00705

Species: Human

Expression System: E. coli

AG-2 Protein, Human, Recombinant (His)

TMPJ-00056

Species: Human

Expression System: HEK293 Cells

OPG Protein, Mouse, Recombinant (His)

TMPJ-00253

Species: Mouse

Expression System: HEK293 Cells

Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)

TMPY-04422

Species: Human

Expression System: Baculovirus Insect Cells

OTUB1 Protein, Human, Recombinant (His)

TMPY-02214

Species: Human

Expression System: E. coli

カタログ番号	製品名
L2191	Anti-Breast Cancer Compound Library		1939 compounds
	A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study；

ライブラリー

Anti-Breast Cancer Compound Library

L2191

Compounds: 1939